TFF1 anticorps (C-Term)

N° du produit ABIN6294640

Cet anticorps Souris Monoclonal détecte spécifiquement TFF1 dans IHC, IF et FACS. Il présente une réactivité envers Humain et Singe.

Aperçu rapide pour TFF1 anticorps (C-Term) (ABIN6294640)

Antigène: TFF1 (Trefoil Factor 1 (TFF1))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TFF1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-TFF1 anticorps

Épitope: C-Term

Fonction: Mouse anti-Human/Monkey TFF1 Antibody [Sodium Azide Free]

Specificité: Cytoplasmic

Purification: A C-terminus peptide was used as the immunogen for the TFF1 antibody.

Immunogène: A C-terminus peptide was used as the immunogen for the TFF1 antibody.

Information d'application

Indications d'application: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur TFF1

Antigène: TFF1 (Trefoil Factor 1 (TFF1))

Autre désignation: Trefoil factor 1

Sujet:

Target Description: It recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60 % of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

Gene Symbol: TFF1///BCEI///PS2

ID gène: 7031

UniProt: P04155

Pathways: EGFR Signaling Pathway